In this paper, a mathematical model is developed to Immune Support simulate the activation of regulatory T lymphocytes dynamics.The model considers the adaptive immune response and consists of epithelial cells, infected cells, free virus particles, helper and cytotoxic T lymphocytes, B lymphocytes, and regulatory T lymphocytes.A mathematical analys
Rationale, design, and cohort enrolment of a prospective observational study of the clinical performance of the new contraceptive implant (Femplant) in Pakistan
Syed Khurram Azmat,1 Waqas Hameed,1 Anja Lendvay,2 Babar Tasneem Shaikh,3 Ghulam Mustafa,1 Muhammad Ahmed Siddiqui,1 Sajid Brohi,1 Asif Karim,1 Muhammad Ishaque,1 Wajahat Hussain,1 Mohsina Bilgrami,1 Paul J Feldblum2 1Research, Monitoring and Evaluation Department, Marie Stopes Society, Karachi, Pakistan; 2FHI 360, Durham, NC, USA; 3Health Services
Humanized substitutions of Vmat1 in mice alter amygdala-dependent behaviors associated with the evolution of anxiety
Summary: The human vesicular monoamine transporter 1 (VMAT1) harbors unique substitutions (Asn136Thr/Ile) that affect monoamine uptake into synaptic vesicles.These substitutions are absent in all known mammals, suggesting their contributions to distinct aspects of human behavior modulated by monoaminergic transmissions, such as emotion and Compact
A quick Heuristic and a general search algorithm for traveling salesman problem
This paper puts forward a constructive heuristic algorithm called the method Black Walnut of inserting the minimum neighbor edge from outside to the center (IMNEFOTC) that can be applied to solve large-scale and ultra-large-scale travelling salesman problems.Through it and the randomized greedy heuristic algorithm (RGH) which greedy heuristic algor
Using phenomenography to inform curriculum development in the areas of Digital Curation and Digital Sustainability
A British university is proposing to introduce two new postgraduate certificate qualifications in Digital Curation and Digital Sustainability.The proposed courses are intended to formalise this knowledge into a curriculum that enables professional practitioners working in related areas to develop their knowledge of how to manage digital assets in a